Research in the group addresses four key areas, integrating molecular insights with technological development to advance our understanding of molecular function, disease, and biotechnological innovation.
Membrane Protein Function
This research area investigates the function of membrane proteins. A particular focus is on G protein-coupled receptors (GPCRs), which regulate key physiological processes and constitute major drug targets. As part of the ERC Starting Grant ‘Decoding the Molecular Logic of GPCR Signaling,’ the group develops single-molecule and microfluidic approaches to study the dynamic behavior and interactions of GPCRs at the molecular level, aiming to generate new insights for drug development.
Biosensing & Diagnostics
In this research area, we develop innovative biosensing and diagnostic platforms for highly sensitive protein analysis and biomarker detection. The group designs microfluidic systems with integrated optics to create novel methods for protein analysis and diagnostic instruments for personalized medicine.
Biomolecular Condensates
Research in this area explores biomolecular condensates that govern cellular organization and are linked to diseases such as cancer and neurodegeneration. By leveraging optics-integrated microfluidics and highly sensitive biophysical methods, the molecular and biophysical mechanisms of biomolecular phase separation are studied to deepen our understanding of fundamental processes in health and disease.
Enzyme Engineering
This research area focuses on enzyme engineering for biotechnological and therapeutic applications. Using droplet microfluidics, the group aims to optimize enzyme functionality to enhance their efficiency and stability for sustainable bioproduction, environmental biotechnology, and pharmaceutical applications.